If I have power to the coil but no power out can the pick up in the distributor cause this you have a 1993 E-250 van?

Yes, a faulty pickup coil in the distributor can prevent power from reaching the ignition system, resulting in no spark and thus no power out to the engine. If the pickup coil is malfunctioning or has failed, it won't generate the necessary signal to trigger the ignition module. Checking the pickup coil's resistance and ensuring proper connections can help diagnose the issue. If the pickup coil is defective, replacing it may resolve the problem.