If a two stroke is being turned which of the adjustments should be done first?

When tuning a two-stroke engine, the first adjustment should typically be the idle screw, which controls the engine's idling speed. Once the idle is set correctly, adjust the air-fuel mixture screw to ensure optimal combustion and performance. After these initial adjustments, you can then fine-tune the high-speed mixture if needed. Always make small adjustments and test the engine's response after each change.