How did Spider-Man 2099 get his powers?

Spider-Man 2099, also known as Miguel O'Hara, gained his powers through a genetic experiment gone wrong. While attempting to recreate the original Spider-Man's abilities, he was exposed to a serum that caused his DNA to merge with that of a spider. This transformation granted him enhanced strength, agility, and spider-like abilities, setting him apart as a futuristic version of the iconic superhero.