How do you change the high mount brake light on a 2006 Honda Odyssey?

The bulb replacement is quite simple. You need a standard screwdriver and a phillips. Take the standard screwdriver and pry the two panels off of the side of the light. You don't need to use much force as these are only clipped in. Next unscrew both screws from the light on either side. Once the screws are loose, the light will tilt forward. Lift the light up as you remove it. The light bulb is on the right side and requires about a 1/2 turn towards you before it slips out. The factory bulb is a Stanley 921 - 12volt 18watt bulb. You should be able to find this at your local auto parts store. The bulb simply pulls out, no need to twist. Replacement is the reverse. I suggest using a kleenex or a cotton cloth on the bulb to avoid any fingerprint marks which may shorten the life of the bulb. Twist the socket away from you to tighten. Angle the light down to insert back into the space. Tighten the screws and gently push the two screw covers back into place. You may need to apply a little bit of pressure to side to squeeze them back into place. You're done!