What is the derivation of clearance?

Clearance is derived from the relationship between the rate of drug elimination from the body and its concentration in the plasma. Mathematically, it is defined as the volume of plasma from which a substance is completely removed per unit time, typically expressed in units like mL/min. The formula for clearance (Cl) is Cl = (Rate of elimination) / (Plasma concentration), where the rate of elimination is often measured in mg/min and plasma concentration in mg/mL. This concept is crucial in pharmacokinetics for understanding drug dosing and the duration of drug action in the body.