Christopher Columbus did not specifically "conquer" people in the traditional sense, but his voyages led to the European colonization of the Americas, impacting various Indigenous populations. His expeditions in the late 15th century primarily affected the Taino and Arawak peoples of the Caribbean, particularly on islands like Hispaniola. The arrival of Columbus and subsequent European settlers brought disease, violence, and enslavement, leading to significant declines in these Indigenous populations.
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