Why proximal muscles are commonly affected in myopathies?

Proximal muscles are commonly affected in myopathies due to their reliance on specific muscle fibers that are often more susceptible to metabolic and inflammatory processes. These muscles, which include those in the shoulders, hips, and thighs, are typically involved in core stability and limb movement, making them more vulnerable to dysfunction. Additionally, many myopathies target the muscle's structural components, such as the sarcomeres or membranes, which can particularly impact proximal muscle strength and function. As a result, weakness in these areas is often one of the first clinical signs of myopathy.