Most drugs -- like speed (amphetamines or methamphetamines), opiates, cocaine, or Ecstasy -- leave your system in about 72 hours (3 days). But you might want to wait at least 5 days, just to be safe.
The exception to this is marijuana. Since THC stores itself in your fat cells, you basically have to work it off, like, exercise it off, which takes anywhere from 2 to 6 weeks.
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