How many people in the world has Lebers Congenital Amaurosis?

Leber's Congenital Amaurosis (LCA) is a rare genetic eye disorder, affecting approximately 1 in 50,000 to 1 in 100,000 live births. Given the global population, this suggests that there are likely between 140,000 to 280,000 individuals with LCA worldwide. However, exact numbers can vary due to underdiagnosis and differences in population genetics.