Yes, you can start a sentence with the Word "my." Here are a few examples:
My favorite color is blue.
My dog always greets me at the door when I come home.
My goal for this year is to learn a new language.
My parents are coming to visit us next weekend.
My car broke down on the way to work this morning.
Starting a sentence with "my" is perfectly grammatical and common in everyday writing and speech.
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