It depends on the species. But if it has pincers (pinching mouthparts) or a stinger, i don't think you wanna pick it up. If there's more you want to know, here's a site that'll help:
http://www.insectidentification.org/insects-by-state.asp?thisState=Florida
if you scroll to the bottom of the site page, you can sort out what kind of bug you're looking for.
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