To depressurize the fuel system in a 2000 Ford F-150, first locate the fuel pump relay in the fuse box and remove it. Then, start the engine and let it run until it stalls, which will relieve pressure in the fuel lines. After the engine stops, turn the ignition off and wait a few moments before proceeding with any repairs or maintenance. Always take safety precautions, such as wearing gloves and working in a well-ventilated area.
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