Can an unemployed single mom and college student get a tax refund check?

Well, that depends. The tax refunds that people get every year are income tax, which is so named because it is based on income. If you are unemployed, or without income, there may not be a lot of tax there to refund. The idea of a refund is that you get back what you paid in the first place. If you had no income, then a refund is unlikely, although depending on whatever other source of income it is that enables you to survive, it is possible. Just fill out the 1040EZ to see how it works out in your situation.