What are the best settings for capturing high-quality headshots?

To capture high-quality headshots, use a wide aperture (around f/2.8 to f/5.6) for a blurred background, set a low ISO (around 100-400) for less noise, and use soft, natural lighting or a diffused flash. Position the subject in front of a plain background and focus on the eyes for sharpness. Adjust the white balance to match the lighting conditions and consider using a reflector for fill light.