In truth, tornadoes can strike virtually anywhere in the U.S. except perhaps northern Alaska, where it is generally too cold for thunderstorms, let alone tornadoes.
However, some regions are certainly more prone to tornadoes than others. This is because of the various factors require for tornado formation including wind shear and a collision between air masses of very different temperatures and/or dew points. Certain regions see such favorable tornado-forming factors more often, and to a greater degree than others.
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