That is an incredibly broad question, one that is very difficult to answer. I won't even consider the resulting conduct problems and psychotic behavior which have resulted in countless accidents and overdoses.
Yes these drugs can kill you combined with alcohol or other powerful CNS depressants, such as opiates and strong benzos. All of these drugs have one thing in common: total body shut down, CNS depressant, pop a few of these with some liquor and your DONE, pop a few of these in combination of one another, take a few Xanax, take a few Seroquel, take a few Ambien and some Valium then try to take a walk down the street and you've picked 3 fights, lost every one of them, get elbow-striked in the head by a police officer and are now under arrest for public delirium and resisting arrest.
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