What do you do when wife says she not in love with me anymore?

She is confused with her life. There could be lot of factors contributing her confusion. Most common issue is routine life style, and husband is not the same person he once used to be. Case like this, you need to give her time to think and figure out what she wants. Mean time, be supportive and let her know you love her and always be here for her. Women are very complicated to understand.. They are very emotional people, and most of times they don't even know what they want.