Can you take excedrin migraine 4 hours after taking ibuprofen?

The short answer is yes. ibuprofen and Aspirin are both drugs that are non-steroidal anti-inflammatory drugs (NSAIDS). If you took a standard dose of aspirin for pain (325-650mg) and were still experiencing some discomfort you can take so ibuprofen. I would recommend taking it with food to reduce stomach upset.