Aspirin and ibuprofen belong to a group of drugs called NSAIDs (Non Steroidal Anti inflammatory Drugs). The all help block pain and inflammation by inhibiting COX, an enzyme responsible for prostaglandins etc. Stop COX and you reduce or stop and further inflammation.
Aspirin, Ibuprofen and the like are highly acidic and even on the own can cause indigestion and stomach problems. Together, the side effects just multiply.
Sometime low dose aspirin is used to prevent cardiac problems such as blood clots and to improve circulation. There is some evidence that concomittant NSAIDs with Aspirin will reduce the efficacy of the antiplatelet activity. Dr Chris
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