How did early European settlers most change the lives of Native Americans?

Early European settlers profoundly altered the lives of Native Americans primarily through the introduction of new diseases, which decimated indigenous populations lacking immunity. Additionally, the settlers' demand for land led to displacement and the disruption of traditional ways of life, including hunting, farming, and social structures. Trade relationships were established, but these often favored Europeans and further entrenched dependency. Overall, the settlers' arrival initiated a period of significant cultural, social, and economic upheaval for Native American communities.