What types of macromolecules yield large numbers of ATP?

Carbohydrates, particularly glucose, yield large amounts of ATP through cellular respiration, including glycolysis and the Krebs cycle. Fats (lipids), especially triglycerides, provide even more ATP per molecule due to their higher energy content and the beta-oxidation process. Proteins can also be used for energy, but they typically yield less ATP compared to carbohydrates and fats, as they must first be deaminated and converted into intermediates of the Krebs cycle. Overall, fats are the most energy-dense macromolecules, followed by carbohydrates.