If nondisjunction occurs during meiOSis, it results in the improper separation of chromosomes, leading to gametes with an abnormal number of chromosomes. When these gametes fuse during fertilization, the resulting zygote may have an extra chromosome (trisomy) or a missing chromosome (monosomy). This can lead to genetic disorders, such as Down syndrome, which is caused by an extra copy of chromosome 21. Nondisjunction can occur in either meiOSis I or meiOSis II, with differing impacts on the resulting gametes.
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