Can MS affect the Peripheral nervous system?

Multiple sclerosis (MS) primarily affects the central nervous system (CNS), which includes the brain and spinal cord. However, it can indirectly impact the peripheral nervous system (PNS) through the effects of CNS lesions, leading to symptoms such as muscle weakness, sensory disturbances, and coordination issues. These symptoms arise from disrupted communication between the CNS and the PNS, but MS itself does not directly target peripheral nerves.