Males are often more affected by certain genetic disorders, especially those linked to the X chromosome, because they have only one X chromosome (XY), while females have two (XX). If a recessive disorder is carried on the X chromosome, a male with the affected X will express the disorder, while a female would need two affected X chromosomes to show the same effect. In a Punnett square, if a carrier mother (X^aX) and a father with the disorder (X^aY) are crossed, the results show a 50% chance for male offspring (X^aY) to be affected and 25% chance for female offspring (X^aX^a) to be affected, highlighting the higher risk for males.
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