Which is stronger 50 mg methadone or 50 mg oxycodone?

Methadone is stronger than oxycodone by up to 5 to 8 times depending on individual differences. Methadone can be used for pain but the typical doses of methadone for narcotic withdrawal are less than would be used for pain. One Word of caution, methadone has a longer withdrawal cycle than oxycodone and can last up to two weeks. If the intention is getting off the oxys I would suggest suboxone. Getting off of methadone can be much more difficult than getting off oxys. Having said that, Methadone can work quite well for people with chronic IBS where other anti-diarrheals do not work. Methadone can turn into a life long maintenance, so you should very carefully weigh the alternatives, and if the only alternative is Methadone, then God help you and best of luck. If there are any other alternatives other than methadone, try that first. Methadone should only be the very last resort. Methadone will not provide the long term euphoria that oxys provide. So if the intent is recreational use, you will soon lose the euphoric feeling but still experience withdrawals which by many accounts is far worse than oxys. Methadone is not well suited for recreational use, so if that is the root of the question, do not take it, or you will be sorry. If it is the last resort, it can be a life saver.