How a person become mad it is related to science give short answer?

Madness is NOT a medical or commanly accepted legal term.

I think you ment to answer two questions that I will try to "re-phrase" (or re-state for you...)

"How can a person become mad?"

I think that this your first question.

You then ask how the understanding of madness can be explained by Science.

There is NO simple answer.

Mental illness (a more acceptable way of describing madness; used by mental health professionals) is probably the most complex diagnostic problem faced by doctors.

Science and Medicine are closely related. They are, however, different. Science attempts to get ever closer to reproducible and verifible Truth. Medicine tries to cure illness, relieve pain and suffering within an ethical framework while using the truths sometimes obtained through science.

Firstmate