The answer to this question is unknown, as leopard geckos would never be found in the water, much less under it. Most reptiles, however, can hold their breath for a very long time, and have low oxygen requirements. A leopard gecko that wound up under water (for whatever reason, it's hard to fathom), would probably get water in its nostrils and possibly its lungs, however. This may lead to a respiratory infection afterward.
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