Can Tylenol with Codeine interact with an anti-diarrheal?

Yes, Tylenol with Codeine can interact with certain anti-diarrheal medications, particularly those that contain diphenoxylate or loperamide. Both codeine and these anti-diarrheals can cause constipation as a side effect, which may be compounded when taken together. It's important to consult a healthcare provider before combining these medications to avoid potential adverse effects.