West Nile virus primarily affects neuronal cells in the central nervous system, leading to neurological symptoms. It can also infect other cell types, including macrophages and dendritic cells, which play a role in the immune response. Birds are the primary reservoir hosts, while mosquitoes serve as vectors for transmission to humans and other animals. Overall, the virus has a broad host range, affecting various species, but its most significant impact is on the nervous system.
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