Does smoking interfere with the effects of Wellbutrin?

Yes, smoking can interfere with the effects of Wellbutrin (bupropion). Smoking increases the metabolism of the drug, which may reduce its effectiveness in treating depression or aiding in smoking cessation. Additionally, nicotine can affect neurotransmitter systems that Wellbutrin targets, potentially diminishing its therapeutic effects. It's important for individuals on Wellbutrin to discuss their smoking habits with their healthcare provider for optimal treatment outcomes.