Can you connect internal hard disk to ps2 via usb?

No, you cannot directly connect an internal hard disk to a PlayStation 2 via USB. The PS2 does not support USB connections to internal drives. However, you can use an external USB hard drive with the appropriate format and compatible software, such as Open PS2 Loader, to run games from it. Alternatively, you can use a network adapter to connect a compatible IDE hard drive directly to the PS2.