Can Tylenol and Excedrin Migraine be taken together?

No. You should check the ingredients in the Excedrin Migraine. Two tablets contain 500 mg of aspirin and 500 mg of acetaminophen plus 65 mg of caffeine. You should not take more aspirin. It can cause stomach bleeding. If that dose is ineffective perhaps you should be evaluated by a neurologist and try to find a prescription drug to treat your migraines. There are several extremely ones available.