Can systemic mastocytosis cause changes in the brain?

Systemic mastocytosis, a condition characterized by an abnormal accumulation of mast cells in various tissues, can potentially affect the brain indirectly through the release of mediators like histamine and cytokines. These substances may influence neurological functions and contribute to symptoms such as headaches, cognitive changes, or mood disturbances. However, direct structural changes in the brain due to systemic mastocytosis are not well-documented and require further research for a clearer understanding.