Can dilantin be mixed with another medication?

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---- Interactions searched:

* Dilantin (phenytoin) * Zoloft (sertraline) ---- 1 Interaction found:

# Dilantin (phenytoin) and Zoloft (sertraline) (Moderate Drug-Drug) PROBLEM: Two case reports suggest that sertraline may significantly increase phenytoin levels when used concomitantly. The mechanism is thought to be related to inhibition of CYP450 2C9 phenytoin metabolism by sertraline. Other hydantoins may also be affected.

POSSIBLE SOLUTION: Clinical and laboratory monitoring for increased hydantoin levels and toxicity is recommended whenever sertraline is added or dosage is changed. Patients should be advised to notify their physician if they experience symptoms of toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia). ----