What negative effects did the Colombian exchanges have on America?

The Colombian Exchange had several negative effects on America, notably the introduction of diseases such as smallpox, measles, and influenza, which decimated Indigenous populations who had no prior immunity. Additionally, the influx of European settlers led to the displacement and marginalization of Native American tribes, disrupting their societies and cultures. The introduction of new agricultural practices and livestock also resulted in environmental changes that altered ecosystems and traditional ways of life.