Can Sudafed cause a false positive UA?

Yes, Sudafed (pseudoephedrine) can potentially cause a false positive on a urine drug screen (UA) for amphetamines. This is due to its chemical structure, which can sometimes be misidentified by testing methods. However, confirmatory tests, such as gas chromatography-mass spectrometry (GC-MS), can differentiate between pseudoephedrine and actual illicit amphetamines. If there is a concern about false positives, it's advisable to inform the testing facility about any medications taken.