Domestic ferrets possible predators would be like hawks, owls, or any larger carnivorous mammals (dogs, coyotes, etc) would hunt them given the opportunity.
Ferrets don't have any natural instincts against predators, because they are so domesticated and rely on humans, they do not know to be scared of other animals.
Black footed ferrets natural enemies includes coyotes, great-horned owls, golden eagles, prairie falcons, badgers, bobcats and foxes.
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